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daptomycin  (Merck & Co)

 
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    Structured Review

    Merck & Co daptomycin
    Images from PET scan of individual rats from each group. The arrow indicates the location of the implant. ( A ) S. aureus -infected rats at days 10, 20, and 31. ( B ) Uninfected rats at days 10, 20, and 31. ( C ) S. epidermidis -infected rat at days 7, 17, and 31. Images from S. epidermidis -infected rat are from the same rat at different time points. ( D ) S. aureus -infected rat treated with <t>daptomycin</t> and rifampicin on day 31.
    Daptomycin, supplied by Merck & Co, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/daptomycin/product/Merck & Co
    Average 86 stars, based on 1 article reviews
    daptomycin - by Bioz Stars, 2026-05
    86/100 stars

    Images

    1) Product Images from "[ 18 F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model"

    Article Title: [ 18 F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model

    Journal: The Journal of Infectious Diseases

    doi: 10.1093/infdis/jiaf594

    Images from PET scan of individual rats from each group. The arrow indicates the location of the implant. ( A ) S. aureus -infected rats at days 10, 20, and 31. ( B ) Uninfected rats at days 10, 20, and 31. ( C ) S. epidermidis -infected rat at days 7, 17, and 31. Images from S. epidermidis -infected rat are from the same rat at different time points. ( D ) S. aureus -infected rat treated with daptomycin and rifampicin on day 31.
    Figure Legend Snippet: Images from PET scan of individual rats from each group. The arrow indicates the location of the implant. ( A ) S. aureus -infected rats at days 10, 20, and 31. ( B ) Uninfected rats at days 10, 20, and 31. ( C ) S. epidermidis -infected rat at days 7, 17, and 31. Images from S. epidermidis -infected rat are from the same rat at different time points. ( D ) S. aureus -infected rat treated with daptomycin and rifampicin on day 31.

    Techniques Used: Infection

    Colony-forming units (CFU) for each group. Data points represent mean CFU of 3 technical replicates from 1 implant. Bars represent median. Kruskal-Wallis test with post hoc Dunn's test. Uninfected, day 10 (n = 7). S. epidermidis , day 7 (n = 6). S. aureus , day 10 (n = 7). Uninfected, day 20 (n = 7). S. epidermidis , day 17 (n = 7). S. aureus , day 20 (n = 8). Uninfected, day 31 (n = 8). S. epidermidis , day 31 (n = 4). S. aureus , day 31 (n = 6). S. aureus DAP + RIF, day 31 (n = 8). DAP/RIF = daptomycin + rifampicin; SA = S. aureus ; SE = S. epidermidis ; UI = uninfected.
    Figure Legend Snippet: Colony-forming units (CFU) for each group. Data points represent mean CFU of 3 technical replicates from 1 implant. Bars represent median. Kruskal-Wallis test with post hoc Dunn's test. Uninfected, day 10 (n = 7). S. epidermidis , day 7 (n = 6). S. aureus , day 10 (n = 7). Uninfected, day 20 (n = 7). S. epidermidis , day 17 (n = 7). S. aureus , day 20 (n = 8). Uninfected, day 31 (n = 8). S. epidermidis , day 31 (n = 4). S. aureus , day 31 (n = 6). S. aureus DAP + RIF, day 31 (n = 8). DAP/RIF = daptomycin + rifampicin; SA = S. aureus ; SE = S. epidermidis ; UI = uninfected.

    Techniques Used:

    Interleukin-10 (IL-10) concentrations in plasma. Each point shows mean value of 1–2 technical replicates from 1 rat. Bars represent median. The lower limit of detection was 7.278 pg/ml. Plasma samples below the measurable concentration were set at a default 7.278 pg/ml to avoid skewing of data. Kruskal-Wallis with post hoc Dunn's test of day 31 groups. DAP/RIF = daptomycin + rifampicin; SA = S. aureus ; SE = S. epidermidis ; UI = uninfected.
    Figure Legend Snippet: Interleukin-10 (IL-10) concentrations in plasma. Each point shows mean value of 1–2 technical replicates from 1 rat. Bars represent median. The lower limit of detection was 7.278 pg/ml. Plasma samples below the measurable concentration were set at a default 7.278 pg/ml to avoid skewing of data. Kruskal-Wallis with post hoc Dunn's test of day 31 groups. DAP/RIF = daptomycin + rifampicin; SA = S. aureus ; SE = S. epidermidis ; UI = uninfected.

    Techniques Used: Clinical Proteomics, Concentration Assay



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    daptomycin  (Merck & Co)
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    Images from PET scan of individual rats from each group. The arrow indicates the location of the implant. ( A ) S. aureus -infected rats at days 10, 20, and 31. ( B ) Uninfected rats at days 10, 20, and 31. ( C ) S. epidermidis -infected rat at days 7, 17, and 31. Images from S. epidermidis -infected rat are from the same rat at different time points. ( D ) S. aureus -infected rat treated with <t>daptomycin</t> and rifampicin on day 31.
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    Images from PET scan of individual rats from each group. The arrow indicates the location of the implant. ( A ) S. aureus -infected rats at days 10, 20, and 31. ( B ) Uninfected rats at days 10, 20, and 31. ( C ) S. epidermidis -infected rat at days 7, 17, and 31. Images from S. epidermidis -infected rat are from the same rat at different time points. ( D ) S. aureus -infected rat treated with <t>daptomycin</t> and rifampicin on day 31.
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    Images from PET scan of individual rats from each group. The arrow indicates the location of the implant. ( A ) S. aureus -infected rats at days 10, 20, and 31. ( B ) Uninfected rats at days 10, 20, and 31. ( C ) S. epidermidis -infected rat at days 7, 17, and 31. Images from S. epidermidis -infected rat are from the same rat at different time points. ( D ) S. aureus -infected rat treated with <t>daptomycin</t> and rifampicin on day 31.
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    Image Search Results


    Images from PET scan of individual rats from each group. The arrow indicates the location of the implant. ( A ) S. aureus -infected rats at days 10, 20, and 31. ( B ) Uninfected rats at days 10, 20, and 31. ( C ) S. epidermidis -infected rat at days 7, 17, and 31. Images from S. epidermidis -infected rat are from the same rat at different time points. ( D ) S. aureus -infected rat treated with daptomycin and rifampicin on day 31.

    Journal: The Journal of Infectious Diseases

    Article Title: [ 18 F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model

    doi: 10.1093/infdis/jiaf594

    Figure Lengend Snippet: Images from PET scan of individual rats from each group. The arrow indicates the location of the implant. ( A ) S. aureus -infected rats at days 10, 20, and 31. ( B ) Uninfected rats at days 10, 20, and 31. ( C ) S. epidermidis -infected rat at days 7, 17, and 31. Images from S. epidermidis -infected rat are from the same rat at different time points. ( D ) S. aureus -infected rat treated with daptomycin and rifampicin on day 31.

    Article Snippet: The antibiotics were daptomycin (“Cubicin”, Merck Sharp & Dohme, Copenhagen, Denmark), rifampicin (“Rifadin”, Sanofi S.r.I., Milan, Italy), and a single dose of preoperatively administered cefuroxime (“Cefuroxim”, Fresenius Kabi, Copenhagen, Denmark).

    Techniques: Infection

    Colony-forming units (CFU) for each group. Data points represent mean CFU of 3 technical replicates from 1 implant. Bars represent median. Kruskal-Wallis test with post hoc Dunn's test. Uninfected, day 10 (n = 7). S. epidermidis , day 7 (n = 6). S. aureus , day 10 (n = 7). Uninfected, day 20 (n = 7). S. epidermidis , day 17 (n = 7). S. aureus , day 20 (n = 8). Uninfected, day 31 (n = 8). S. epidermidis , day 31 (n = 4). S. aureus , day 31 (n = 6). S. aureus DAP + RIF, day 31 (n = 8). DAP/RIF = daptomycin + rifampicin; SA = S. aureus ; SE = S. epidermidis ; UI = uninfected.

    Journal: The Journal of Infectious Diseases

    Article Title: [ 18 F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model

    doi: 10.1093/infdis/jiaf594

    Figure Lengend Snippet: Colony-forming units (CFU) for each group. Data points represent mean CFU of 3 technical replicates from 1 implant. Bars represent median. Kruskal-Wallis test with post hoc Dunn's test. Uninfected, day 10 (n = 7). S. epidermidis , day 7 (n = 6). S. aureus , day 10 (n = 7). Uninfected, day 20 (n = 7). S. epidermidis , day 17 (n = 7). S. aureus , day 20 (n = 8). Uninfected, day 31 (n = 8). S. epidermidis , day 31 (n = 4). S. aureus , day 31 (n = 6). S. aureus DAP + RIF, day 31 (n = 8). DAP/RIF = daptomycin + rifampicin; SA = S. aureus ; SE = S. epidermidis ; UI = uninfected.

    Article Snippet: The antibiotics were daptomycin (“Cubicin”, Merck Sharp & Dohme, Copenhagen, Denmark), rifampicin (“Rifadin”, Sanofi S.r.I., Milan, Italy), and a single dose of preoperatively administered cefuroxime (“Cefuroxim”, Fresenius Kabi, Copenhagen, Denmark).

    Techniques:

    Interleukin-10 (IL-10) concentrations in plasma. Each point shows mean value of 1–2 technical replicates from 1 rat. Bars represent median. The lower limit of detection was 7.278 pg/ml. Plasma samples below the measurable concentration were set at a default 7.278 pg/ml to avoid skewing of data. Kruskal-Wallis with post hoc Dunn's test of day 31 groups. DAP/RIF = daptomycin + rifampicin; SA = S. aureus ; SE = S. epidermidis ; UI = uninfected.

    Journal: The Journal of Infectious Diseases

    Article Title: [ 18 F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model

    doi: 10.1093/infdis/jiaf594

    Figure Lengend Snippet: Interleukin-10 (IL-10) concentrations in plasma. Each point shows mean value of 1–2 technical replicates from 1 rat. Bars represent median. The lower limit of detection was 7.278 pg/ml. Plasma samples below the measurable concentration were set at a default 7.278 pg/ml to avoid skewing of data. Kruskal-Wallis with post hoc Dunn's test of day 31 groups. DAP/RIF = daptomycin + rifampicin; SA = S. aureus ; SE = S. epidermidis ; UI = uninfected.

    Article Snippet: The antibiotics were daptomycin (“Cubicin”, Merck Sharp & Dohme, Copenhagen, Denmark), rifampicin (“Rifadin”, Sanofi S.r.I., Milan, Italy), and a single dose of preoperatively administered cefuroxime (“Cefuroxim”, Fresenius Kabi, Copenhagen, Denmark).

    Techniques: Clinical Proteomics, Concentration Assay